Nioxin vs Monat vs Rogaine

Nioxon vs Monat vs Rogaine

While perusing the land of Facebook I was drawn to an image (shown below) illustrating the advantages of one product over two others. With my interest piqued I spent the better part of an evening researching it’s claims. I believe we all fall victim to the whirlwind of information flashed before our eyes. There is so much knowledge at our fingers tips it can be challenging to decipher fact from fiction.

Errors and Clarifications

The first error the author made was when they classified Nioxin, a company as a product. I am assuming the author intended to compare Nioxin’s Hair Regrowth Treatment for Men and Rogaine to the Monat product: Intense Repair Treatment.

The second error was when it compared the three products unfairly. No attempt was made to compare each item in a like manner, essentially the author was comparing apples to oranges.

The next error was that the active and inactive ingredients were inaccurately listed. If you consult the following data you will see that Acetamide MEA, Cocamide MEA, PEG-150 distearate, Tocopherol, Cocamidopropyl betaine, Diazolidinyl, Sodium Laureth sulfate, Tetrasodium EDTA, Methylparaben PEG-150 distearate and Propylparaben are not on the ingredient list for Nioxin’s Hair Regrowth Treatment.
The active ingredient of Nioxin’s Hair Regrowth Treatment for Men is 5% Minoxidil. The inactive ingredients are Alcohol, Propylene Glycol and Purified Water. [3]

The active ingredient of Rogaine is Minoxidil 5%. The inactive ingredients of Rogaine are butane, butylated hydroxytoluene, cetyl alcohol, citric acid, glycerin, isobutane, lactic acid, polysorbate 60, propane, purified water, SD alcohol 40-B, stearyl alcohol.

The product I assume the author wishes to compare from Monat is their Intense Repair Treatment, which claims to be a patented biometric peptide formula, that has “higher proven results than other leading hair loss brands” and its “clinical results prove significant results in just 90 days” [1]

The Intense Repair Treatment does not use the terms active and inactive ingredients, instead the terms ‘key ingredient’ and ‘ingredients’ are used. The key ingredient is Capixyl [1]. However on the main Monat website this ingredient is not mentioned. On the main Monat website it states that the product’s ingredients are water, butylene glycol, acetyl tetrapeptide-3, Trifolium Pratense Flower Extract, hydrolyzed wheat protein, dextran, xanthan gum, pvp, cocamidopropyl-pg-dimonium, chloride, benzyl alcohol, dehydroacetic acid, fragrance.

According to another source the ingredient list of Capixyl is: Butylene Glycol, water, Dextran, Acetyl Tetrapeptide-3, Trifolium Pratense Flower Extract which matches up with most of the ingredients within the Intense Repair Treatment. [2]

How are the terms key, active and inactive ingredients defined?
According to the World Health Organization the term active ingredient is defined as:

“active pharmaceutical ingredient (API) Any substance or combination of substances used in a finished pharmaceutical product (FPP), intended to furnish pharmacological activity or to otherwise have direct effect in the diagnosis, cure, mitigation, treatment or prevention of disease, or to have direct effect in restoring, correcting or modifying physiological functions in human beings.”

An inactive ingredient or vehicle is an inactive substance mixed with an active ingredient to give bulk to a medicine. [4]

I have found no pharmaceutical definitions for key ingredients.

What do these three products do?

Nioxin Hair Regrowth Treatment for men and Rogaine have identical active ingredients.
Active Ingredient: Minoxidil 5%.

“Minoxidil applied to the scalp is used to stimulate hair growth in adult men and women with a certain type of baldness. The exact way that this medicine works is not known. If hair growth is going to occur with the use of minoxidil, it usually occurs after the medicine has been used for several months and lasts only as long as the medicine continues to be used. Hair loss will begin again within a few months after minoxidil treatment is stopped. In the U.S., this medicine is available without a prescription.” [5]

Monat Intense Repair Treatment
Key Ingredient: Capixyl (not listed as an active ingredient, see above)

There is no information on Pubmed about Capixyl. [6]

There appears to be no evidence-based data to suggest Capixyl or the Monat Intense Repair Treatment has any affect on the regrowth of hair.

Conclussion

According to my research Minoxidil is the only drug proven to regrow hair. Monat’s claim that Capixyl (or Monat’s Intense Repair Treatment) can regrow hair is anecdotal at best.

[1] “Intense Repair Treatment” Monat Intense Repair Treatment. Hair Canada. Web. 8 December 2017. <
[2] “Capixyl TM” Propspector. UL. Web. 8 December 2017 < https://www.ulprospector.com/en/na/PersonalCare/Detail/4501/191081/Capixyl>
[3] ”Nioxin Hair Regrowth Treatment for Men” JC Penney. Web. 8 December 2017. < http://haircanada.net/index.php/monat-products/intense-repair-treatment-monat/>
[4] “Defintion of Active Pharmaceutical Ingredient” WHO. World Health Organization, July 2011. Web. 8 December 2017. <https://www.jcpenney.com/p/nioxin-hair-regrowth-treatment-for-men-30-day-supply-2-oz/pp5005120081?pTmplType=regular&rrec=true&rrplacementtype=product1_rr> http://www.who.int/medicines/areas/quality_safety/quality_assurance/DefinitionAPI-QAS11-426Rev1-08082011.pdf>.
[5] “Minoxidil (on the skin)” Minoxidil. NCBI. 1 November 2017. Web. 8 December 2017. < https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0011238/?report=details>
[6] “No result found for Capixl” < https://www.ncbi.nlm.nih.gov/search/?term=Capixyl>

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